Methodology checklist - intervention studies
Study reference There was adequate concealment of allocation Participants receiving care were kept 'blind' to treatment allocation Care providers were kept 'blind' to treatment allocation Outcome assessors were kept 'blind' to participants’ exposure to the intervention Use of unvalidated or intermediate Selective outcome reporting on basis of the results Loss to follow-up/incomplete outcome data described and acceptable Analysis by intention to treat Other limitations Comments
Sharma, 2013 yes no no no no no yes yes
Kim et al., 2016 yes no yes no no no yes yes
Lambrechts et al., 2017 yes no unclear unclear no no yes yes
Zare, et al., 2017 yes no unclear unclear no no yes yes yes

The mAD may be effective as a cotherapy treatment for adults with refractory epilepsy and decrease 2.19 times seizure frequency in comparison with control groups. Trials with the more tolerant dietary regime, with larger sample size and longer duration, should be performed in future.

AED was continued unchanged for at leat the 2 months, but when necessary, the drugs were changed in both groups.

Small number of patients, difference between groups in medication use.