Onderzoek naar diagnostische tests
Study reference 1 Was the spectrum of patients representative of the patients who will receive the test in practice? 2 Is the reference standard likely to correctly classify the target condition? 3 Is the time period between reference standard and index test short enough to be reasonably sure that the target condition did not change between the two tests? 4 Did the whole sample or a random selection of the sample, receive verification using a reference standard? 5 Did patients receive the same reference standard irrespective of the index test result? 6 Was the reference standard independent of the index test (i.e. the index test did not form part of the reference standard)? 7+8 Were the index test results interpreted without knowledge of the results of the reference standard and vice versa? 9 Were the same clinical data available when test results were interpreted as would be available when the test is used in practice? 10 Were uninterpretable/ intermediate test results reported? 11 Were withdrawals from the study explained? Level of evidence* Comments

Colon, 2009

yes no yes yes yes no no yes yes NA B

- fault in data reporting (patient characteristics about 54 patients, while only 51 were included according to text)

- final diagnosis is not necessarily the right diagnosis (patients had no surgery enabling to check diagnosis)

- relevant outcomes as sensitivity are not reported, only raw data



* 2 Is the reference standard likely to correctly classify the target condition?
- Final diagnosis was used as a reference standard, there was no definitive proof (no surgery or other outcome results of treatment were available to check the validity of diagnosis)

* Level of evidence
- Only raw data reported, no sensitivity scores calculated
- Small study population (n=51)
- Retrospective study