Economic evaluations (transferability)
Study reference Study characteristics Patient characteristics The relevant technology is comparable to the one that shall be used in the decision country? Intervention The comparator is relevant to the one that is relevant in the decision country? Comparator(s) Based on the quality appraisal, what is quality of the economic evaluation? Acceptable quality? Overall conclusion Transferability

Hawkins et al., 2005

Type of study

Model based economic evaluation

Country

United Kingdom

Perspective

Health care perspectiv

 

Type of study

Model based economic evaluation

 

Country

United Kingdom

 

Perspective

Health care perspectiv

Type of study

Model based economic evaluation

 

Country

United Kingdom

 

Perspective

Health care perspectiv

 

Generalized epilepsy

Combination therapy: 1) Topiramate


Yes

Placebo (monotherapy)


Yes

18, high

yes

Transferable

Maltoni & Messori, 2003

Type of study

Model based economic evaluation

Country

United Kingdom

Perspective

Health care perspective

Generalized epilepsy

Topiramate


Yes

Placebo


Yes

12, moderate

yes

Transferable

Marson et al., 2007

Type of study

Model based economic evaluation

Country

United Kingdom

Perspective

Health care perspective

Generalized epilepsy

Children and adults

1) Valproate; 2) Lamotrigine; 3) Topiramate


Yes

Yes (except for valproate, this drug is not allowed in young women).


Yes

19, high

yes

Transferable except for valproate: this drug is not allowed in young women.

Remak et al., 2003

Type of study

Model based economic evaluation

Country

United Kingdom

Perspective

Health care perspective

Generalized epilepsy

1) Valproate; 2) Topiramate; 3) Lamotrigine


Yes

All drugs compared side-by-side.


Yes

17, high

yes

Transferable (except for topiramate. This drug is no first choice treatment).

Remak et al., 2004

Type of study

Trial based economic evaluation

Country

United Kingdom

Perspective

Health care perspective

Generalized and partial epilepsy

1) Clobazam,; 2) Gabapentin; 3) Lamotrigine; 4) Topiramate; 5) Vigabatrin


Yes (except valproate, this drug is not allowed in young women).

All drugs compared side-by-side.


Yes

14, moderate

yes

Transferable (except for vigabatrine, this drug is not in guideline).