Economic evaluations (summary)
Study reference Study characteristics Patient characteristics Is the new intervention cost-effective? Are the outcomes of the economic evaluation uncertain and/or variable? Balance between health benefits, side effects, and risk Overall conclusion Transferability (see table transferability) Generalizability of the study results Implementation problems

Hawkins et al., 2005

Type of study

Model based economic evaluation

Country

United Kingdom

Perspective

Health care perspectiv

 

Type of study

Model based economic evaluation

 

Country

United Kingdom

 

Perspective

Health care perspectiv

Type of study

Model based economic evaluation

 

Country

United Kingdom

 

Perspective

Health care perspectiv

 

Generalized epilepsy


Yes (Topiramate)


Suboptimal

No (no adverse events of ADR taken into account).

Transferable

Generalizable

No

Maltoni & Messori, 2003

Type of study

Model based economic evaluation

Country

United Kingdom

Perspective

Health care perspective

Generalized epilepsy


Yes (Topiramate)


Yes

Unclear (adverse events are measured but not reported).

Transferable

Generalizable

No

Marson et al., 2007

Type of study

Model based economic evaluation

Country

United Kingdom

Perspective

Health care perspective

Generalized epilepsy

Children and adults


Yes (Topiramate)


Yes

Yes

Transferable

Generalizable except for valproate: this drug is not allowed in young women.

No, except for valproate: this drug is not allowed in young women.

Remak et al., 2003

Type of study

Model based economic evaluation

Country

United Kingdom

Perspective

Health care perspective

Generalized epilepsy


Yes (Topiramate)


Yes

Yes (separate sensitivity analyses using side-effect specific utilities).

Transferable

Generalizable

No (except for topiramate. This drug is no first choice treatment).

Remak et al., 2004

Type of study

Trial based economic evaluation

Country

United Kingdom

Perspective

Health care perspective

Generalized and partial epilepsy


Yes (Topiramate)


Yes

Unclear (side effects measured but not reported).

Transferable

Generalizable

No