Economic evaluations (summary)
Study reference Study characteristics Patient characteristics Is the new intervention cost-effective? Are the outcomes of the economic evaluation uncertain and/or variable? Balance between health benefits, side effects, and risk Overall conclusion Transferability (see table transferability) Generalizability of the study results Implementation problems

Bowen et al., 2012

Type of study
Model based

Country
Canada

Perspective  
health care

Refractory epilepsy


yes

yes

QALY gain

No (no side effects/adverse events) included in the model

Yes

Generalizable

Widjaja et al., 2011

Type of study

Model and trial based

Country

Canada

Perspective

health care

Intractable epilepsy

(children)


yes

yes

Seizure reduction

No (not taken into account)

Yes

Generalizable

Picot et al., 2016

Type of study 
Trial-based (cohort study)

Country 
France

Perspective   
societal perspective (but a limited one without productivity losses)

Refractory epilepsy


yes


yes, study is not randomized

Seizure freedom

No (no side effects/adverse events) included in the model

Yes

Generalizable

No