Methodology checklist - intervention studies
Study reference There was adequate concealment of allocation Participants receiving care were kept 'blind' to treatment allocation Care providers were kept 'blind' to treatment allocation Outcome assessors were kept 'blind' to participants’ exposure to the intervention Use of unvalidated or intermediate Selective outcome reporting on basis of the results Loss to follow-up/incomplete outcome data described and acceptable Analysis by intention to treat Other limitations Comments
Noachtar, 2008 yes yes yes no no no yes yes yes

- The majority of the subjects were diagnosed as juvenile myoclonic epilepsy (88.5% in the intervention group, 98.3% in the contro group), others were diagnosed juvenile absence epilepsy)

- 122 patients were randomized, but 1 did not receive medication, so 121 were included in the intent to treat

- About patients with IGE, not only about JME: a small part (8/121) has juvenile absence epilepsy

Biton et al., 2005 unclear yes yes yes no no unclear yes unclear

- small study population

- majority of patients (64%)were treated with two AEDs before topiramate was added